Because we, like most of our readers, are small (although, almost medium-sized is an appealing goal), this musing makes a lot of sense.
As the world comes closer together, "mom and pop shops" can now be "global micro-brands" (pretty good spin, eh?) without much more effort than it would take to build local business, perhaps even less, as the internet is a genius form of communication when used correctly.
Stay small, stay in control, and stick to your vision. There is a lot of hope and success out there for the little guy!